The efficacy of Doxycycline – Rifampin – Gentamicin, Doxycycline – Rifampin– Ciprofloxacin and Doxycycline – Co-trimoxazole – Gentamicin in complicated brucellosis

Comparison of the efficacy of three drug regimens Doxycycline – Rifampin – Gentamicin, Doxycycline – Rifampin– Ciprofloxacin and Doxycycline – Co-trimoxazole – Gentamicin on relapse of disease in patients with complicated brucellosis: A clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017052734154N1

Enrollment

Registered

2017-06-30

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brucellosis. Brucellosis

Interventions

Intervention 1: Intervention group: Doxycycline 100 mg PO BID and Rifampicin 600 mg IV daily and PO after discharge and Gentamicin 80 mg IV TDS and Streptomycin 1 gr IM after discharge. This regimen

Treatment - Drugs

Intervention group: Doxycycline 100 mg PO BID and Rifampicin 600 mg IV daily and PO after discharge and Gentamicin 80 mg IV TDS and Streptomycin 1 gr IM after discharge. This regimen prescribed for 6

Intervention group: Doxycycline 100 mg PO BID and Rifampicin 600 mg IV daily and PO after discharge and Ciprofloxacin 400 mg IV and 500 mg PO BID after discharge. This regimen prescribed for 6 months.

Intervention group: Doxycycline 100 mg PO BID and Co-trimoxazole (trimethoprim 80 mg/5ml and sulfamethoxazole 400 mg/5 ml IV BID and PO after discharge and Gentamicin 80 mg IV TDS and Streptomycin 1

Eligibility

Sex/Gender

All

Age

17 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: Brucella endocarditis; Neurobrucellosis; OCP consumption; Phenytoin consumption; Brucellosis relapse Exclusion criteria: Stevens–Johnson Syndrom; Anaphylaxis; Pancreatitis; Pseudomembranous colitis; Renal failure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Relaps. Timepoint: 6 months. Method of measurement: Physical examination and Wright>or =1/40 and 2-ME>or=1/80.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRaziyeh Kazemi

Islamic Azad University of Shahrood

kazemi.raziyeh95@gmail.com+98 23 3239 1796

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026