Destructive lesions of the knee joint cartilage. Disorder of cartilage, unspecified
Conditions
Interventions
Intervention 1: Control group: This group will receive only autologous mesenchymal stem cells. One to two million cells are spilled in the alginate bed and the medium is changed every three days until
Treatment - Other
Control group: This group will receive only autologous mesenchymal stem cells. One to two million cells are spilled in the alginate bed and the medium is changed every three days until the alginate is
Intervention group: This group receives autologous chondrogenic pre-differentiated mesenchymal stem cells (MSCs). One to two million cells are spilled in the alginate bed and the medium is changed eve
Sponsors
Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: aged between 15 years to 40 years; the lesion between 2.5 and 6 square centimeters; the lesions of trauma sports and non-sports injury; femoral condyle internal or external lesions Exclusion criteria: Obesity; corticosteroid injection less than 3 months ago; hyaluronic acid injection less than 6 months ago; varus and valgus more than 5 degree; diabetes type one and two; autoimmune disease; malnutrition; certain neurological diseases; history of allergy; infectious diseases
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Articular cartilage lesions of the knee. Timepoint: 3.6.12,18 weeks. Method of measurement: MRI and diagnostic arthroscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycosaminoglycans, collagen, gene and protein expression of, agercan, collagen type II and sox9. Timepoint: Eighteenth week. Method of measurement: biochemical, molecular and immunocytochemistry analysis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarjam Goudarzi
Hamadan university of medical sciences
Outcome results
None listed