Skip to content

"Investigation of the Effect of cervical Mobilization on Migraine by functional Magnetic Resonance Imaging (fMRI) findings"

Investigation of the Effect of upper cervical Mobilization on Migraine headaches by functional Magnetic Resonance Imaging (fMRI) findings with Trigeminal nerve stimulation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170524034119N3
Enrollment
30
Registered
2022-07-03
Start date
2022-04-04
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine without aura

Interventions

Intervention 1: Intervention group: Mobilization of the first and second and third cervical spine in the form of extension, rotation and lateral flexion glides to both sides, which is done by the radi

Sponsors

Tarbiat Modares University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 55 Years

Inclusion criteria

Inclusion criteria: Diagnosis of episodic migraine without aura by a neurologist The minimum duration of the disease is one year Number of attacks at least 2-5 attacks per month No change in medications in the last three months

Exclusion criteria

Exclusion criteria: Positive response to VBI tests of Alar ligament, Transverse ligament, Tectorial membrane Any abnormal signs in the structural condition of the cervical spines in X-Ray findings Symptoms of Vertebrobasilar Insufficiency (VBI) Malignancy, Diabetes, Rheumatoid disease, peripheral neuropathy, Fibromyalgia, Osteoporosis, history of surgery, radiculopathy, disc dysfunction or soft tissue elements in the neck Performing Nerve Block or non-drug treatment (Physiotherapy, Manual therapy, Acupuncture, etc.) in the last 6 months

Design outcomes

Primary

MeasureTime frame
"Brain fMRI findings". Timepoint: before the intervention, 5 weeks after the start of the intervention (after the intervention). Method of measurement: fMRI image analysis.;"Midas Disability Questionnaire Score (MIDAS)". Timepoint: Before the intervention and 12 weeks after the last intervention session. Method of measurement: "The MIDAS (Migraine Disability Assessment) questionnaire".;"Mean severity of attacks in people with migraine (VAS)". Timepoint: Before the intervention, after ten session intervention and 12 weeks after the last intervention session. Method of measurement: The visual analog scale (VAS).;Questionnaire score of the impact of headache on the life of people with migraine (HIT-6). Timepoint: Before the intervention, after ten session intervention and 12 weeks after the last intervention session. Method of measurement: Headache Impact Test-6 (HIT-6) for Migraine Patients questionnaire.

Secondary

MeasureTime frame
Active cervical flexion movement. Timepoint: Before the intervention and after the last intervention session. Method of measurement: iPhone inclinometer app.;Active cervical extension movement. Timepoint: Before the intervention and after the last intervention session. Method of measurement: iPhone inclinometer app.;Active cervical lateral flexion movement. Timepoint: Before the intervention and after the last intervention session. Method of measurement: iPhone inclinometer app.;Active cervical rotation movement. Timepoint: Before the intervention and after the last intervention session. Method of measurement: iPhone inclinometer app.;Flexion-rotation test (FRT). Timepoint: Before the intervention and after the last intervention session. Method of measurement: iPhone compass app.;Head postural assessment (FHP). Timepoint: Before the intervention and after the last intervention session. Method of measurement: Photographic images by Canon IXY 12 digital camera from lateral and sagittal plane in standing position with measurement of craniovertebral angle (CVA) showing the position of the head in relation to the C7 vertebra.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarid Bahrpeyma

Tarbiat Modares University

bahrpeyf@modares.ac.ir+98 21 8288 3819

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026