Metamphetamine Dependency. Dependence syndrome A cluster of behavioural, cognitive, and physiological phenomena that develop after repeated substance use and that typically include a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite
Conditions
Interventions
Intervention 1: The first group will receive n-acetylcysteine 1200 mg daily in two divided doses for 12 weeks. Intervention 2: The second group will receive placebo for 12 weeks.
Treatment - Drugs
Placebo
The first group will receive n-acetylcysteine 1200 mg daily in two divided doses for 12 weeks.
The second group will receive placebo for 12 weeks.
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years Methamphetamine dependence, as assessed by the substance abuse section of the Structured Clinical Interview for DSM-IV On methadone maintenance treatment Seeking treatment for methamphetamine use Written consent to participate in the study
Exclusion criteria
Exclusion criteria: Serious medical illness Current neurological disorder including organic brain diseases, dementia or psychiatric disorders unrelated to methamphetamine abuse, including schizophrenia and bipolar disorder or attempted suicide within 30 days before commencement of the study Present or recent use (within 2 weeks) of over-the-counter or prescription drug that would be expected to have major interaction with n-acetylcysteine Current dependence on cocaine, alcohol and benzodiazepine History of head trauma Pregnancy Metabolic diseases such as diabetes and neurological diseases such as epilepsy Impairment of liver function tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methamphetamine craving. Timepoint: The beginning of the study - every two weeks until the twelfth week. Method of measurement: Visual analogue scale (VAS).;Methamphetamine severity dependence. Timepoint: The beginning of the study - every two weeks until the twelfth week. Method of measurement: Addiction Severity Index (ASI). | — |
Secondary
| Measure | Time frame |
|---|---|
| Negative urine test for methamphetamine. Timepoint: Once every fifteen days. Method of measurement: methamphetamine urine test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Asariyan
Kashan University of Medical Sciences
Outcome results
None listed