Evaluation of the efficacy of adding Domperidone for the treatment of refractory gastroesophageal reflux disease

Evaluation of the efficacy of adding Domperidone to a proton pump inhibitor for the treatment of refractory gastroesophageal reflux disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017052134070N1

Enrollment

Registered

2017-06-09

Start date

2016-12-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease

Interventions

Intervention 1: Intervention group: pantoprazole 40mg (BD) + Domperidone 10mg (TID). Intervention 2: Control group: pantoprazole 40mg (BD) + placebo tablet (TID).

Treatment - Drugs

Intervention group: pantoprazole 40mg (BD) + Domperidone 10mg (TID)

Control group: pantoprazole 40mg (BD) + placebo tablet (TID)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with gastroesophageal reflux disease that do not partially or completely respond to treatment after taking twice daily proton pump inhibitor for one month Exclusion criteria: age below 18 or above 80 years; severe cardiopulmonary, renal or liver failure; pregnancy; breast feeding; history of gastro-esophageal surgery or malignancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Response to treatment. Timepoint: One month after starting therapy. Method of measurement: questionnnaires.	—

Secondary

Measure	Time frame
Quality of life. Timepoint: One month after starting tratment. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Tarang Taghvaei

Mazandaran University of Medical Sciences

tarang_taghvaei@yahoo.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026