Effect of topical application of breast milk on umbilical cord separation time in very Low Birth Weight (VLBW) Infants

Comparison of topical application of breast milk and routine procedure on umbilical cord separation time and the bacterial colonization in very Low Birth Weight (VLBW) Infants

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017052110026N8

Enrollment

Registered

2017-09-19

Start date

2017-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal skin infection. Neonatal skin infection

Interventions

Intervention 1: In the control group (dry care), the umbilical cord is allowed to dry in open air gradually. Then, within 2-4 hours after birth, a culture swab from the umbilical stump is sent to labo

Prevention

In the control group (dry care), the umbilical cord is allowed to dry in open air gradually. Then, within 2-4 hours after birth, a culture swab from the umbilical stump is sent to laboratory as baseli

In the intervention group (breast milk use on the umbilical cord) 3-4 drops of breast milk for a maximum of 8 hours after birth is rubbed on umbilical stump. This will continue every 8 hours to two d

Eligibility

Sex/Gender

All

Age

No minimum to 1 Months

Inclusion criteria

Inclusion criteria: Inclusion criteria for this study: preterm birth (pre-maturity), weighing less than 1500 grams Exclusion criteria for this study: major congenital anomalies, presence of asphyxia and hypoxia, umbilical catheter

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Day of umbilical cord separation. Timepoint: at the 3th and 7th days of life. Method of measurement: daily recorded sheets.	—

Secondary

Measure	Time frame
Bacterial colonization. Timepoint: at the 3th, 7th days of life. Method of measurement: swap- culture.;Omphalitis. Timepoint: at the 3th, 7th days of life. Method of measurement: daily recorded sheets.;Exudate. Timepoint: at the 3th, 7th days of life. Method of measurement: daily recorded sheets.;Granulation tissue. Timepoint: at the 3th, 7th days of life. Method of measurement: daily recorded sheets.;Sepsis. Timepoint: at the 3th, 7th and 15th days of life. Method of measurement: daily recorded sheets.	—

Measure

Time frame

Bacterial colonization. Timepoint: at the 3th, 7th days of life. Method of measurement: swap- culture.;Omphalitis. Timepoint: at the 3th, 7th days of life. Method of measurement: daily recorded sheets.;Exudate. Timepoint: at the 3th, 7th days of life. Method of measurement: daily recorded sheets.;Granulation tissue. Timepoint: at the 3th, 7th days of life. Method of measurement: daily recorded sheets.;Sepsis. Timepoint: at the 3th, 7th and 15th days of life. Method of measurement: daily recorded sheets.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Amir Mohammad Armanian

Department of pediatrics , Isfahan University of Medical Sciences, Isfahan, Iran

armanian@med.mui.ac.ir+98 131294044

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026