Schizophrenia. Schizophrenia are generally identified by distorting the basic characteristics of thinking and perception, and affects that are inappropriate or not. Clear consciousness and intellectual capacity are usually maintained although certain cognitive deficits
Conditions
Interventions
Intervention 1: In the intervention group: Simvastatin Tablets, 20 mg orally, once a day for 6 weeks. Intervention 2: Control group: Placebo tablet, 20 mg oral, once a day for 6 weeks.
Treatment - Drugs
In the intervention group: Simvastatin Tablets, 20 mg orally, once a day for 6 weeks
Control group: Placebo tablet, 20 mg oral, once a day for 6 weeks
Sponsors
Vice Chancellor for Research, Ahwaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for this study: having a diagnosis of schizophrenia according to DSM-IV-TR? a PANSS total score of 50 or higher on the scale? the scale PANSS negative score of 15 or more of 70-18 years, during a period of at least 1 year of disease onset. Exclusion criteria for this study: patients with a history of sensitivity to statins ? active liver disease or increase stability and unexplained liver enzymes? kidney failure? medical condition serious? drug abuse or drug dependence during the previous month? pregnancy? lactation? there at the same time other psychiatric disorders requiring drug therapy? desire to commit suicide or homicide? possession of dementia and cognitive impairment serious? unrelated to schizophrenia? organic disease of the brain such as seizures and severe mental retardation and Parkinson's disease, Taking anti psychotic oral over the past month or long-acting injections over the past three months? the concomitant use of other drugs such as antidepressants or lithium? etc. which may be a result of treatment interfere? schizophrenia resistant to treatment? lack of response to an adequate dose and appropriate for typical anti psychotic drugs.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emotional withdrawal. Timepoint: Before the study? week third? sixth week. Method of measurement: PANSS (Positive and Negative Symptom Scale). | — |
Secondary
| Measure | Time frame |
|---|---|
| Social withdrawal. Timepoint: Before the experiment three weeks after the intervention? six weeks after intervention. Method of measurement: PANSS (Positive And Negative Symptom Scale). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDoctor Seyed Mohammad Seyed Ghaffari Dezffooli
Ahwaz Jundishapur University of Medical Sciences
Outcome results
None listed