Effect of ibuprofen and ibuprofen lysine on pain after root canal treatment

Comparison between different ibuprophen formulations with two prescription methods on postoperative pain after root canal treatment of teeth with symptomatic irreversible pulpitis; a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017051934030N1

Enrollment

120

Registered

2017-07-24

Start date

2017-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after root canal treatment.

Interventions

Intervention 1: intervention group1: will use Ibuprophen 400 mg or Ibuprophen lysine 400g regulary every 6 hours at least 24 hours. Patients should mark the severity of their pain in the VAS. Interve

Treatment - Drugs

intervention group1: will use Ibuprophen 400 mg or Ibuprophen lysine 400g regulary every 6 hours at least 24 hours. Patients should mark the severity of their pain in the VAS.

intervention group 2:will use Ibuprophen 400 mg or Ibuprophen lysine 400g , if necessary. In the patients description the maximum dose is prescribed. Patients should mark the severity of their pai

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1.Healthy patient with a first or second mandibular or maxillary molar tooth with irreversible pulpitis and have moderate to sever pain to the cold pulp test at the time of treatment and do not have periapical radiolucency appearance without sensivity to percussion. 2.All the patient have no clinical swelling. 3.No patient had a draining sinus tract. 4.A positive response to an electrical pulp teste in addition to a prolonge response with moderate to sever pain to a cold pulp test ( endo-Ice) confirmed the clinical diagnosos of acute irreversible pulpitis for each tooth. exclusion criteria : 1.Patients under 18. 2.The presence of any systemic disorders sensivity that prevent the use of ibuprophen. 3.Patient are allergic to local anesthetetics or sulfites. 4.Having a tooth not suitable for restoration or having serious pweriodontal disease that render the tooth unsuitable for endodontic treatment. 5.Patients who have use any type of analgesic medication. 6.Patient are unable to give informed consent. 7.Pregnant patient or breast fiding during study. 8.Failure to provide pain relief. 9.History of peptic ulcer or GI bleeding.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The amount of pain after root canal treatment. Timepoint: every 6 hour to 72 hour after root canal treatment. Method of measurement: Visual analogue scale(VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactdr Ali haeri tabatabaei

Shahid beheshti dental school

Ali9352@yahoo.com+98 21 2217 5350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026