chronic rhinosinusitis with and without polyps. chronic sinusitis
Conditions
Interventions
Intervention 1: Intervention group: nasal spray fluticasone once a day, 2 puff in each nasal cavity with calcitriol spray once a day (equivalent 2000 unit vitamin D or 50 micro gram calcitriol) for on
Treatment - Drugs
Intervention group: nasal spray fluticasone once a day, 2 puff in each nasal cavity with calcitriol spray once a day (equivalent 2000 unit vitamin D or 50 micro gram calcitriol) for one month
control group: nasal spray fluicasone and placebo
Sponsors
Vice chancellor for research, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all patients older than 18 years with the diagnostic criteria for chronic rhinosinusitis with polyposis based on the EPOS 2012 criteria. Exclusion criteria: smoking; sensitivity to vitamin D3; pregnancy; use of systemic steroids in last month; immunosuppressive drugs; history of any endocrine disease, malignancy, acute rhinosinisitis during study, surgery for rhinosinusitis, complication of rhinosinusitis, calcification of soft tissue and hypercalcemia.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chronic rhinosinusitis. Timepoint: Before intervention and 1and 3 months after intervention. Method of measurement: VAS, SNOT22 and Lund Kennedy scoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug adverse effect such as nasal irritation. Timepoint: during study period. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarnaz Hashemian
Hamadan University of Medical Sciences
Outcome results
None listed