Investigating the effects of dexmedetomidine infusion on sadation

Investigating the effects of dexmedetomidine infusion compared to placebo on sedation in patients undergoing upper limb surgery with nerve blocks

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170516033992N17

Enrollment

Registered

2025-09-27

Start date

2025-10-22

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper limb surgery with nerve blocks.

Interventions

Intervention 1: Intervention group:After nerve block, dexmedetomidine infusion will be given at a concentration of 4 micrograms/cc at a dose of 0.1 micrograms/kg for 10 minutes and then 0.05 microgram

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adult patients (18-65 years) Candidates for elective upper limb surgery

Exclusion criteria

Exclusion criteria: Patients who refuse to participate in the trial Pregnancy Breastfeeding Severe renal or hepatic impairment Cardiovascular impairment Cognitive impairment Inability to cooperate Having a history of allergy to dexmethodamide

Design outcomes

Primary

Measure	Time frame
Sedation Quality During Surgery in Patients Undergoing Upper Limb Surgery Under Nerve Blocks. Timepoint: At the initiation, during the maintenance infusion, and at the end of sedation. Method of measurement: Ramsay Sedation Scale criteria.;Duration of sedation. Timepoint: Up to 24 hours after surgery. Method of measurement: Kornometer (minutes).;Pain after surgery. Timepoint: Up to 24 hours after surgery. Method of measurement: Visual analogue scale (VAS).	—

Measure

Time frame

Sedation Quality During Surgery in Patients Undergoing Upper Limb Surgery Under Nerve Blocks. Timepoint: At the initiation, during the maintenance infusion, and at the end of sedation. Method of measurement: Ramsay Sedation Scale criteria.;Duration of sedation. Timepoint: Up to 24 hours after surgery. Method of measurement: Kornometer (minutes).;Pain after surgery. Timepoint: Up to 24 hours after surgery. Method of measurement: Visual analogue scale (VAS).

—

Secondary

Measure	Time frame
The first time of analgesic. Timepoint: Up to 24 hours after the surgery. Method of measurement: Kornometere (minutes).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Tohid Karami

Oroumia University of Medical Sciences

karami.t@umsu.ac.ir+98 44 3222 2010

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026