Investigating the effect of dexamethasone and Dexmedetomidine in preventing nausea and vomiting after hysterectomy

Comparison of dexmedetomidine and dexamethasone efficacy in preventing postoperative nausea and vomiting after laparotomic hysterectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170516033992N15

Enrollment

165

Registered

2024-10-10

Start date

2024-11-21

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention group: Patients in the first group will receive 8 mg of dexamethasone intravenously in a single dose after induction of anesthesia and before skin incision. Intervention 2

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Elective laparotomic hysterectomy Age between 18 and 65 years

Exclusion criteria

Exclusion criteria: Receiving any anti-nausea and vomiting medication in 24 hours before surgery BMI (Body mass index) above 35 kg/m2 Having allergy to any of the drugs used in this study

Design outcomes

Primary

Measure	Time frame
Having nausea and vomiting. Timepoint: Within 24 hours after the surgery. Method of measurement: Feeling the need to empty the contents of the stomach.;Severity of nausea and vomiting. Timepoint: Within 24 hours after the surgery. Method of measurement: Visual analogue scale (VAS).	—

Secondary

Measure	Time frame
Fentanyl dosage. Timepoint: Based on the dose of fentanyl received during anesthesia. Method of measurement: Milligrams.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Tohid Karami

Oroumia University of Medical Sciences

karami.t@umsu.ac.ir+98 44 3344 5079

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026