Investigating the effect of dexmedetomidine and ketamine-propofol combination on sedation and analgesia in patients undergoing forearm surgeries

Comparison of the effect of dexmedetomidine with ketamine-propofol combination infusion on sedation and analgesia in patients candidates for forearm surgeries under infraclavicular block

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170515033986N7

Enrollment

Registered

2024-11-11

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia and sedation after surgery. Poisoning by, adverse effect of and underdosing of unspecified antiepileptic and sedative-hypnotic drugs

Interventions

Intervention 1: Intervention group: After performing infraclavicular block using ropivacaine 0.5%, patients in first group will receive a combination of 200 mg propofol and 100 mg ketamine in a 50 cc

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients undergoing forearm surgeries Age above 18 years Patients with physical status one and two according to the criteria of the American Anesthesia Association (ASA I, II)

Exclusion criteria

Exclusion criteria: Cardiovascular diseases Lung and liver diseases History of drug addiction Consumption of alcohol or any other substance History of mental illness Allergy to propofol, ketamine and dexmedetomidine drugs Patients who use painkillers 12 hours before surgery Having significant pain other than the forearm

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: After intervention during operation and recovery. Method of measurement: Visual analogue scale (VAS).;Frequency of analgesic prescription. Timepoint: Up to 24 hours after the surgery. Method of measurement: Frequency of administration.;Sedation level. Timepoint: After intervention during operation and recovery. Method of measurement: Ramsay Sedation Score (RSS).	—

Secondary

Measure	Time frame
Nausea and vomiting. Timepoint: Up to 24 hours after the surgery. Method of measurement: Clinical examination.;Hypotension. Timepoint: Up to 24 hours after the surgery. Method of measurement: Blood pressure drop more than 20% of the baseline value based on the monitoring device.;Bradycardia. Timepoint: Up to 24 hours after the surgery. Method of measurement: A heart rate drop of more than 20% of the baseline value based on the monitoring device.	—

Measure

Time frame

Nausea and vomiting. Timepoint: Up to 24 hours after the surgery. Method of measurement: Clinical examination.;Hypotension. Timepoint: Up to 24 hours after the surgery. Method of measurement: Blood pressure drop more than 20% of the baseline value based on the monitoring device.;Bradycardia. Timepoint: Up to 24 hours after the surgery. Method of measurement: A heart rate drop of more than 20% of the baseline value based on the monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Nazli Karami

Oroumia University of Medical Sciences

karami.n@umsu.ac.ir+98 44 3345 7286

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026