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Investigating the effect of dexmedetomidine and nitroglycerin on induced hypotension in rhinoplasty surgery

Comparing the effect of dexmedetomidine and nitroglycerin infusion on induced hypotension inrhinoplasty

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170515033986N6
Enrollment
50
Registered
2024-10-28
Start date
2024-11-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension. Other hypotension

Interventions

Intervention 1: Intervention group: After induction of general anesthesia with 2.5 ug/kg/min propofol and 0.5 ug/kg/min atracurium, the first group (dexmedetomidine group) will receive 1 ug/kg/min de

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients undergoing rhinoplasty surgery Age between 18 to 45 years

Exclusion criteria

Exclusion criteria: Coagulation disorders Having a history of cardiovascular disease and uncontrolled blood pressure History of drug addiction Having a history of disease Allergy to study drugs

Design outcomes

Primary

MeasureTime frame
Hypotension based on mean arterial pressure (MAP) less than 60 mm Hg. Timepoint: After induction of general anesthesia and then every 15 minutes until the end of the surgery. Method of measurement: Monitoring device.

Secondary

MeasureTime frame
Heart rate. Timepoint: After induction of anesthesia and then every 15 minutes until the end of surgery. Method of measurement: Monitoring device.;Nausea and vomiting. Timepoint: At the end of surgery in recovery. Method of measurement: Clinical examination.;Throat pain. Timepoint: At the end of surgery in recovery. Method of measurement: Clinical examination.;Headache. Timepoint: At the end of surgery in recovery. Method of measurement: Clinical examination.;Surgeon's satisfaction with the quality of vision in the surgical field. Timepoint: At the end of surgery. Method of measurement: Likert scale as very bad/bad/moderate/good/excellent.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Nazli Karami

Oroumia University of Medical Sciences

karami.n@umsu.ac.ir+98 44 3345 7286

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026