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Efficasy of transcranial direct current stimulation on dorsolateral prefrontal cortex on BDNF, IL-6, TNF-alpha

Efficasy of transcranial direct current stimulation on dorsolateral prefrontal cortex on BDNF, IL-6, TNF-alpha

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170513033946N5
Enrollment
36
Registered
2019-01-19
Start date
2018-06-22
Completion date
Unknown
Last updated
2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental and behavioural disorders due to use of opioids. Opioid abuse with opioid-induced mood disorder

Interventions

Intervention 1: Intervention group: There will be three groups. Two of them will be intervention groups and the other on will be sham group. One of the groups will receive Anodal tDCS treatment on R-D

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Having informed consent to participate in the research Methadone treatment for at least two weeks before the intervention Age 18- 50 years old Minimum grade education

Exclusion criteria

Exclusion criteria: The absence of more than two sessions Suicidal thoughts or dangers that It is not possible to keep the dosage fixed Having severe psychiatric disorders such as schizophrenia Consuming multiple substance History of injury to the head History of epileptic seizures

Design outcomes

Primary

MeasureTime frame
Brain- derived neurotrophic factor (BDNF). Timepoint: pretest-post test. Method of measurement: Eliza kit.

Secondary

MeasureTime frame
Interleukin 6 (IL-6). Timepoint: pretest-post test. Method of measurement: Eliza kit.;Tumor necrosis factor-( TNF-a). Timepoint: pretest-post test. Method of measurement: Eliza kit.;Quantitative EEG (QEEG). Timepoint: pretest-post test. Method of measurement: Mitsar set.;BART Impassivity. Timepoint: pretest- post test. Method of measurement: BART Impassivity questionnaire.;Craving. Timepoint: pretest- post test. Method of measurement: Desires for Drugs Questionnaire (DDQ).;Sub scale anxiety -DASS. Timepoint: pretest- post test. Method of measurement: depression sub scale(DASS).;Decision making ablity. Timepoint: pretest-post test. Method of measurement: IUWA Gambling Task.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZakaria Eskandari

Zanjan University of Medical Sciences

mohsendadashi@zums.ac.ir+98 24 3354 4001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 14, 2026