Effect of combined zinc and vitamin E supplementation in treatment of women with gestational diabetes mellitus

The effect of combined magnesium and vitamin E on pregnancy outcomes, inflammatory factors and oxidative stress biomarkers in patients with gestational diabetes

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170513033941N56

Enrollment

Registered

2019-04-15

Start date

2018-09-17

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes mellitus. Unspecified diabetes mellitus in pregnancy, childbirth and the puerperium

Interventions

Intervention 1: Intervention group: 250 mg magnesium (21st Century, Arizona, USA) and 400 IU vitamin E (Zahravi, Tabriz, Iran) daily for 6 weeks orally. Intervention 2: Control group: Placebo (Barij E

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with gestational diabetes mellitus. Individuals aged 18 to 40 years.

Exclusion criteria

Exclusion criteria: Exclusion criteria: overt diabetes mellitus Taking any supplements before the intervention Unwillingness to cooperate

Design outcomes

Primary

Measure	Time frame
Hs-CRP. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Elisa kit.	—

Secondary

Measure	Time frame
Nitric oxide. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Newborn's head circumference. Timepoint: Delivery time. Method of measurement: Tape.;Newborn's weight. Timepoint: Delivery time. Method of measurement: Scale.;Polyhydramnios. Timepoint: End-of-trial. Method of measurement: Sonography.;Newborn length. Timepoint: The first 24 h after birth. Method of measurement: Girth measuring tape.	—

Measure

Time frame

Nitric oxide. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Spectrophotometry.;Newborn's head circumference. Timepoint: Delivery time. Method of measurement: Tape.;Newborn's weight. Timepoint: Delivery time. Method of measurement: Scale.;Polyhydramnios. Timepoint: End-of-trial. Method of measurement: Sonography.;Newborn length. Timepoint: The first 24 h after birth. Method of measurement: Girth measuring tape.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZatollah Asemi

Kashan University of Medical Sciences

asemi_z@kaums.ac.ir+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026