Effect of selenium supplementation in treatment of gestational diabetes mellitus

Clinical trial of the effect of selenium supplementation compared with the placebo on gene expression related to insulin and lipid in women with gestational diabetes mellitus

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170513033941N35

Enrollment

Registered

2018-06-20

Start date

2018-05-16

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes mellitus. Unspecified diabetes mellitus in pregnancy, childbirth and the puerperium

Interventions

Intervention 1: Intervention group: Selenium supplements (Nature, California, USA), 200 µg, daily, for 6 weeks orally. Intervention 2: Control group: Placebo (Barij Essence, Kashan, Iran), daily, for

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with gestational diabetes mellitus. Individuals aged 18 to 40 years.

Exclusion criteria

Exclusion criteria: Thyroid disorders Smokers Pre-eclampsia Eclampsia Kidney or liver diseases Requiring insulin therapy during intervention Taking selenium supplements or other antioxidants 3 months before the intervention

Design outcomes

Primary

Measure	Time frame
Expressed levels of PPAR-? gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.	—

Secondary

Measure	Time frame
Expressed levels of GLUT-1 gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of Lp(a) gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of LDL-R gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.	—

Measure

Time frame

Expressed levels of GLUT-1 gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of Lp(a) gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of LDL-R gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZatollah Asemi

Kashan University of Medical Sciences

asemi_z@kaums.ac.ir+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 2, 2026