Depression. Recurrent depressive disorder, current episode moderate.Recurrent depressive disorder, current episode severe without psychotic symptoms
Conditions
Interventions
Intervention 1: In the intervention group 500 mg Echium amoenum extract (capsule) will be administered daily for 8 week . Intervention 2: In The control group 20 mg fluoxetine (capsule) will be admini
Treatment - Drugs
In the intervention group 500 mg Echium amoenum extract (capsule) will be administered daily for 8 week .
In The control group 20 mg fluoxetine (capsule) will be administered daily for 8 weeks .
Sponsors
Vice chancellor for research, Ahvaz Jundishapur University of Medical Science
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria require that the menopausal women have amenorrhea for at least 12 months; the participants age be between 45 and 60 years and Major depression criteria based on DSM-5, According to psychiatrist verdict; patients with moderate to severe depression (14-22 with a test of Hamilton depression score). The exclusion criteria include: patients with depression that have suicidal thoughts; severe depression; Sensitivity to the fluoxetine; Getting any systemic disease such as( high blood pressure;diabetes; renal disease); Taking antidepressant medication; alcohol consumption; Use of herbal medicines for treatment of menopausal symptoms; use of Drugs that interfere with fluoxetine; surgery such as hysterectomy radical women, Vaginoplasty and artificial menopause.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression levels. Timepoint: 0 week, 4 week, 6 week, 8 week. Method of measurement: phycologist and Hamilton questioner. | — |
Secondary
| Measure | Time frame |
|---|---|
| Diarrhea. Timepoint: Daily. Method of measurement: Self report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactmitra tadayon najafabady
ahvaz medical university
Outcome results
None listed