Bedsore. The ulcer appears as a defined area of persistent redness (erythema) in lightly pigmented skin, whereas in darker skin tones, the ulcer may appear with persistent red, blue or purple hues, without skin loss
Conditions
Interventions
Intervention 1: Nifedipine 3% ointment (formulated in the faculty of pharmacy affiliated to Tehran University of Medical Sciences) twice daily topically cover all sores area for 14 days. Intervention
Treatment - Drugs
Placebo
Nifedipine 3% ointment (formulated in the faculty of pharmacy affiliated to Tehran University of Medical Sciences) twice daily topically cover all sores area for 14 days
Sponsors
Vice Chancellor for Research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Critically ill adult patients; with grade 1 or 2 of bedsore; hospitalized in Intensive Care Unit (ICU) for at-least 14 days; without history of nifedipine hypersensitivity reaction. Exclusion Criteria: Patients with severe bedsore requiring antibiotic therapy; worsening of bedsore during treatment course.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grade of bedsore. Timepoint: At ICU admission and then day 14 of hospitalization. Method of measurement: 2-digit Stirling scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Khalili
Tehran University of Medical Sciences
Outcome results
None listed