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Effect of Fexofenadine and fluticasone propionate on the level of transcription factors: GATA-3? ROR?t and FOXP3 in allergic rhinitis patients

A comparison survey of GATA-3, ROR?t and FOXp3 genes expression levels in peripheral blood cells of rhinitis patients, before and after treatment with fexofenadine and fluticasone propionate.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017050233622N2
Enrollment
20
Registered
2017-07-06
Start date
2017-05-31
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinitis patients. Vasomotor and allergic rhinitis and Chronic rhinitis, nasopharyngitis and pharyngitis

Interventions

Drug administration: Fexofenadine: 1 tablet/ day Fluticasone propionate: one puff nasal spray into each nostril/ day.
Treatment - Drugs
Drug administration: Fexofenadine: 1 tablet/ day Fluticasone propionate: one puff nasal spray into each nostril/ day

Sponsors

Vice Chancellor for Research and Technology, Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1- People enter to the study should be at the age of 18 to 60 years, 2- They have to study and signature the testimonial before entrance to the study, 3- lack of abnormality in nasal anatomy, 4- having rhinitis symptoms which is confirmed by specialist physician, 5- not being suffered from: asthma, infectious disease, underlying diseases such as diabetes and chronic inflammatory diseases, 6- In addition, pregnant women, people above 65 and those people who suffer from rhinitis because of Senility will not enter the study. Exclusion criteria: 1- People suffering from infectious diseases or common cold during the period of study, 2- patients taking drugs other than drugs that must consume according to the research plan, during Performance of the project, 3- patients who have a fungal, viral or bacterial disease during the t curse of study, 4- patients who do not follow the recommended instructions. All these people will be excluded from the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
RORgt. Timepoint: Befor treatment and one month After treatment. Method of measurement: Relative expression of RORgt gene measured by Real-time PCR.;GATA3. Timepoint: Befor treatment and After one month treatment. Method of measurement: Relative expression of GATA3 gene measured by Real-time PCR.;FOXP3. Timepoint: Befor treatment and one month After treatment. Method of measurement: Relative expression of FOXP3 gene measured by Real-time PCR.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Gorgin Karaji

School of Medicine, Kermanshah University of Medical Sciences

ali4459@gmail.comali4459@yahoo.com+98 833427461821

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026