Comparison of the effect of Omeprazole, Pantoprazole and Esomeprazole in treatment of laryngopharyngeal reflux

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017050133277N2

Enrollment

Registered

2017-06-02

Start date

2016-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease

Interventions

Intervention 1: tab Esomeprazole 40mg, po, BD for 3 months. Intervention 2: Tab Pantoprazole 40 mg, po, BD for 3 months. Intervention 3: Tab Omeprazole 40 mg, po, BD for 3 months.

Treatment - Drugs

tab Esomeprazole 40mg, po, BD for 3 months

Tab Pantoprazole 40 mg, po, BD for 3 months

Tab Omeprazole 40 mg, po, BD for 3 months

Eligibility

Sex/Gender

All

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: presence of symptoms of laryngopharyngeal reflux; presence of signs of laryngopharyngeal reflux in pharyngeal examinations Exclusion criteria: Recent treatment with antireflux drugs; history of sergury on Stomach and esophagus; history of connective tissue diseas; any benign or malignant lesions of larynx; recieving antiinflammatory drugs either systemic or inhalational

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Globus sensation. Timepoint: before treatment then 3months later. Method of measurement: History.;Number of days with reflux. Timepoint: before treatment then 3months later. Method of measurement: history.;Posr nasal discharge. Timepoint: before treatment then 3months later. Method of measurement: history.;Vocal cord errythema. Timepoint: Befaore and three months after treatment. Method of measurement: Laryngoscopy.;Supraglottic edema. Timepoint: Before and three months after treatment. Method of measurement: Laryngoscopy.;Severity of cough. Timepoint: before treatment then 3months later. Method of measurement: history.;Cough after meals or when lying down. Timepoint: before treatment then 3months later. Method of measurement: history.;Hoarseness. Timepoint: Before and three months after treatment. Method of measurement: Questionnaire.;Heartburn and acid rising feeling. Timepoint: before treatment then 3months later. Method of measurement: history.;Difficulty swallowing. Timepoint: before treatment then 3months later. Method of measurement: taking history.;Difficult breathing. Timepoint: before treatment then 3months later. Method of measurement: taking history.;Interarytenoid edema. Timepoint: Before and three months after treatment. Method of measurement: Laryngoscopy.	—

Measure

Time frame

Globus sensation. Timepoint: before treatment then 3months later. Method of measurement: History.;Number of days with reflux. Timepoint: before treatment then 3months later. Method of measurement: history.;Posr nasal discharge. Timepoint: before treatment then 3months later. Method of measurement: history.;Vocal cord errythema. Timepoint: Befaore and three months after treatment. Method of measurement: Laryngoscopy.;Supraglottic edema. Timepoint: Before and three months after treatment. Method of measurement: Laryngoscopy.;Severity of cough. Timepoint: before treatment then 3months later. Method of measurement: history.;Cough after meals or when lying down. Timepoint: before treatment then 3months later. Method of measurement: history.;Hoarseness. Timepoint: Before and three months after treatment. Method of measurement: Questionnaire.;Heartburn and acid rising feeling. Timepoint: before treatment then 3months later. Method of measurement: history.;Difficulty swallowing. Timepoint: before treatment then 3months later. Method of measurement: taking history.;Difficult breathing. Timepoint: before treatment then 3months later. Method of measurement: taking history.;Interarytenoid edema. Timepoint: Before and three months after treatment. Method of measurement: Laryngoscopy.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNadia Shafiei

Tehran University of Medical Sciences

shafiei_nadia@yahoo.com+98 21 61190

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026