Femoral fracture intraoperative bleeding. Fracture of femur
Conditions
Interventions
Intervention 1: Intervention group: 15 minutes prior to incision, 10 mg/kg tranexamic acid will be administered and will be infused during surgery with dosage of 1 mg/kg/hr till end of the surgery. I
Treatment - Drugs
Placebo
Intervention group: 15 minutes prior to incision, 10 mg/kg tranexamic acid will be administered and will be infused during surgery with dosage of 1 mg/kg/hr till end of the surgery.
Control group: 15 minutes prior to incision, 10 mg/kg normal saline (placebo) will be administered and will be infused during surgery with dosage of 1 mg/kg/hr till end of the surgery.
Sponsors
Vice Chancellor for research of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients candidate for femoral fracture surgery using conture; Class I or II according to ASA classification; aged more than 18 years old. Exclusion criteria: hypersensitivity to tranexamic acid; anemia (hemoglobin lower than 8 gram per 100 milliliter); avoidance from blood transfusion; history of anticoagulant consumption; history of coagulopathies; history of thromboembolism; history of cerebrovascular accidents; history of ischemic heart diseases; pregnancy; major cardiac or pulmonary diseases; hepatic or renal failure; history of epilepsy; history of re-surgery.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss volume in drain reservoir. Timepoint: during operation and till darin discharge. Method of measurement: maximum allowable blood loss formula. | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume of blood transfusion. Timepoint: during operation and during admission. Method of measurement: C.C. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Masoud Parish
Tabriz University of Medical Sciences
Outcome results
None listed