Gastro-oesophageal reflux. Gastro-esophageal reflux disease
Conditions
Interventions
Intervention 1: The intervention group are given quince syrup twice daily with ranitidine syrup for 4 weeks. Intervention 2: The placebo control group are given sugar syrup twice daily with ranitidine
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 4 Years
Inclusion criteria
Inclusion criteria: Patients in the age group of 12 to 48 months. People with at least 2 times a week with common symptoms of reflux disease (heartburn, regurgitation, vomiting, epigastric pain and appropriate weight loss for at least a month Those who are newly diagnosed or who have been suffering from reflux, have not taken any medications for at least one month and will want to start their treatment again
Exclusion criteria
Exclusion criteria: Patients with severe reflux disease (severe onset: symptoms of severe esophagitis, vomiting, life-threatening symptoms such as apnea, pneumonia, esophageal stricture and systemic diseases) due to the need for treatments Another intervention, including surgery or other medications, is withdrawn from the project because of ethical considerations (non-deprivation of the patient and non-risk for the volunteers) Children with a disease (neurological, cardiac, pulmonary, liver and kidney) or mental retardation People who have used other herbal remedies during this period People who need to use chemical drugs during the plan due to the specific disease People with a history of allergy to herbal medicines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of nausea. Timepoint: A week before treatment, the second, fourth and sixth weeks after treatment. Method of measurement: GSQ-YC standard questionnaire.;Numbers of vomiting. Timepoint: A week before treatment, the second, fourth and sixth weeks of treatment. Method of measurement: GSQ-YC standard questionnaire.;Severity of hiccups. Timepoint: The beginning of the week, the second week, the fourth, the sixth. Method of measurement: GSQ-YC standard questionnaire.;Severity of abdominal pain. Timepoint: The beginning of the week, the second week, the fourth, the sixth. Method of measurement: GSQ-YC standard questionnaire.;Freqency of abdominal pain. Timepoint: The beginning of the week, the second week, the fourth, the sixth. Method of measurement: GSQ-YC standard questionnaire.;Severity of regurgitation. Timepoint: The beginning of the week, the second week, the fourth, the sixth. Method of measurement: GSQ-YC standard questionnaire.;Frequency of hiccups. Timepoint: The beginning of the week, the second week, the fourth, the sixth. Method of measurement: GSQ-YC standard questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Refuse to eat. Timepoint: The last week of treatment, the second week of the fourth and sixth treatment. Method of measurement: GSQ-YC standard questionnaire.;Inappropriate weighing. Timepoint: Before starting treatment and then finishing treatment for the sixth week. Method of measurement: Baby growth curve.;Swallowing disorder. Timepoint: Before starting treatment and during treatment until the 6th week. Method of measurement: GSQ-YC standard questionnaire.;Side effects. Timepoint: Any time during treatment. Method of measurement: Baby Nurse Report.;Repeated use of anti-acid. Timepoint: First and second months of treatment. Method of measurement: Baby Nurse Report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Naeimi
Babol University of Medical Sciences
Outcome results
None listed