Pain. Pain Unspecified
Conditions
Interventions
Intervention 1: A capsule of 75 mg Pregabalin (Lyrica) administered two hours before induction of anesthesia in intervention group. Intervention 2: A placebo capsule administered two hrs before induct
Treatment - Drugs
Placebo
A capsule of 75 mg Pregabalin (Lyrica) administered two hours before induction of anesthesia in intervention group
A placebo capsule administered two hrs before induction of anesthesia in control
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: INCLUSION CRITERIA: Age 18-55 years old ASA Class I-II Candidate for elective Septorhinoplasty, Septoplasty or Rhinoplasty Sign informed consent EXCLUSION CRITERIA: Patients with a history of drug or Alcohol abuse Impaired kidney or liver function Antidiabetic, antidepressant, antiepileptic, antihypertension medication Pregnant or breast feeding patients History of hypersensitivity to any of the drugs used in the study Peptic ulcer, NSAID related dyspepsia History of daily intake of analgesics or intake of any analgesics within 24 hours before septoplasty and inability to cooperate
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Pain Score. Timepoint: We Measure Pain at 10 minute pos-extubation, 30 min post-extubation, 60 min post-extubation, 2 hours post-extubation, 6 hours post-extubation and 24 hrs post-extubation. Method of measurement: Visual Analouge Scale of Pain (VAS).;Total fentanyl injected postoperativly. Timepoint: 120 minutes post operative. Method of measurement: Based on PACU documents in microgram.;Total Ibuprofen recived. Timepoint: 24 hours post-extubation. Method of measurement: Miligram units based on participants file and answer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time. Timepoint: the time between cessation of all anesthetics and extubation. Method of measurement: Based on minutes, measured by a clock.;Total remifentanil used during anesthesia. Timepoint: At the time of Extubation. Method of measurement: Measured based on microgram/kg/min.;Postoperative Agitation. Timepoint: Measured in PACU. Method of measurement: Based on Ramsay Sedation Scale.;Post?perative Nausea and Vomiting. Timepoint: During 120 min PACU care; 24 hrs after Extubation. Method of measurement: Obsevation in PACU, Answer of patint after 24 hrs.;Double vision. Timepoint: During 120 min PACU care; 24 hrs after Extubation. Method of measurement: Answer of patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Jalali
Tehran University of Medical Sciences
Outcome results
None listed