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The effect of letrozole / misoprostol compared with placebo / misoprostol in success rate of medical abortion

The effect of letrozole / misoprostol compared with placebo / misoprostol in success rate of medical abortion

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017042933680N1
Enrollment
300
Registered
2017-06-26
Start date
2017-03-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medical abortion. Complication following abortion and ectopic and molar pregnancy, unspecified

Interventions

Intervention 1: The intervention group will receive daily oral dose of 10 mg letrozole 2 days before hospitalization. Third dose of one will receive in time of hospitalization. Intervention 2: The co
Treatment - Drugs
The intervention group will receive daily oral dose of 10 mg letrozole 2 days before hospitalization. Third dose of one will receive in time of hospitalization.
The control group will receive daily oral dose of 10 placebo 2 days before hospitalization. Third dose of one will receive in time of hospitalization.

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Upper 18 years old; Twenty weeks gestational age based on ultrasound; Hemoglobin greater than 10 mg/dl; Diastolic blood pressure less than 95 mmHg; No history of thrombolytic, Cancer and liver disease. Exclusion criteria:Asthma; Hypertension; Porphyritic; Breast; liver disease; Having IUD; Smoking upper twenty cigarettes a day.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Abortion. Timepoint: after intervention. Method of measurement: Sonography.

Secondary

MeasureTime frame
Endometrial thickness. Timepoint: after Intervention. Method of measurement: sonography, Less than twenty millimeters is considered as complete abortion and endometrial thickness greater than twenty millimeters is considered as incomplete abortion.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Taheri

Mashhad University of Medical Sciences

golhasanif1@mums.ac.ir+98 51 32608

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026