Comparison and evaluation of cognitive impairment and cognitive function changes in patients undergoing coronary artery bypass graft surgery after premedication with doxedmodyntidine and midazolam

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170429033680N7

Enrollment

Registered

2018-02-28

Start date

2016-11-02

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary arteries. Other symptoms and signs involving cognitive functions and awareness

Interventions

Intervention 1: Intervention group: premedication with midazolam 0.5 and 1 mg / kg. Intervention 2: Control group: Dexmedetomidine at a dose of 1 microgram per kilogram.

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patient satisfaction On-pump surgery Age 40 to 65 years old

Exclusion criteria

Exclusion criteria: A cardiovascular disease and prolonged CPR DVT history in the last 6 months A history of advanced kidney or lung disease Duration of surgery for more than 5 hours

Design outcomes

Primary

Measure	Time frame
Cognitive function of patients. Timepoint: before and after surgery. Method of measurement: Scale.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: after intervation. Method of measurement: Barometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Rajaei

Mashhad University of Medical Sciences

rajaeim931@mums.ac.ir+98 51 3802 2711

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026