Evaluation of the effect of the compound extract of chicory, globe artichoke and milk thistle on non-alcoholic fatty liver

Evaluation of the effect of the compound extract of Cichorium intybus, Cynara scolymus and Silybum marianum on lipid accumulation in non-alcoholic fatty liver, in comparison with placebo in a randomized double-blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017042824198N2

Enrollment

Registered

2017-11-19

Start date

2017-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatty liver. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group 1: Compound extract of Cichorium intybus, Cynara scolymus and Silybum marianum

twice a day for two months. Intervention 2: Intervention group 2 (control): placebo which is similar to treatment but without herbal extract, twice a day for two months.

Treatment - Drugs

Placebo

Intervention group 1: Compound extract of Cichorium intybus, Cynara scolymus and Silybum marianum

twice a day for two months

Intervention group 2 (control): placebo which is similar to treatment but without herbal extract, twice a day for two months

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who are willing to participate in the clinical trial; age range 20-70 years; diagnosed with nonalcoholic fatty liver disease; not affected with other disease states such as cardiovascular, digestive and endocrine disorders; not using other herbal medications at least 3 months prior to intervention. Exclusion criteria: diagnosis of other disease states such as cardiovascular, digestive and endocrine disorders; taking herbal medications, showing allergic responses, unwillingness to participate

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Level of lipid accumulation in liver. Timepoint: before intervention and 2 months after intervention. Method of measurement: sonography.	—

Secondary

Measure	Time frame
Liver enzyme assay. Timepoint: before intervention and after 2 months. Method of measurement: measurement in blood serum.;Fasting blood glucose. Timepoint: before intervention and after 2 months. Method of measurement: measurement in blood serum.;Lipid profile. Timepoint: before intervention and after 2 months. Method of measurement: measurement in blood serum.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hamidollah Afrasiabian

Salamat Pouyan Novin Afra Pharmaceutical Company

rezahododi.1367@gmail.com+98 912 371 0023

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026