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Effect of vitamin D on inflammation and muscle damage in athletes

Evaluating the effect of Cholecalciferol supplementation on inflammatory markers and muscle damage indices in soccer players after a simulated soccer match

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017042613678N27
Enrollment
22
Registered
2017-06-26
Start date
2016-08-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: inflammation. Condition 2: muscle damage. - -

Interventions

Intervention 1: Experimental group will receive supplement for 8 weeks (each week they should eat one 50000 IU cholecalciferol pearl). After 8 weeks, players will participate in a simulated soccer ma
1 ´ 20 m at maximal running speed
4 s recovery
3 ´ 20 m at a running speed corresponding to 55% of individual VO2max
3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed by a rest period of 3 min. Altogether, five15 min exercise bl
Treatment - Other
Experimental group will receive supplement for 8 weeks (each week they should eat one 50000 IU cholecalciferol pearl). After 8 weeks, players will participate in a simulated soccer match at the test
3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed
Control group will receive placebo for 8 weeks (each week they should eat one oral paraffin pearl). After 8 weeks, players will participate in a simulated soccer match at the test day. The protocol of
3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed by a rest period of 3

Sponsors

Vice Chancellor for research of Urmia university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: soccer players who want to collaboration; players who regularly and consistently participate in soccer practices and matches(at least 4 month passed from starting this sport); age group between 18 to 30 years old; healthy players without any injury, cardio-metabolic disease, orthopedic and inflammatory disease; players without any acute liver disease, biliary, kidney and digestive disease; players with no history of kidney stone and hyperparathyroidism and osteomalasia or osteoporosis and sarcoidosis; lack of vitamin D supplementation at least for 8 weeks before the study beginning; lack of using drugs which can affect vitamin D level and its metabolism and function such as steroid and anti-epileptic drugs; lack of using certain drugs such as acetaminophen and anti-inflammatory drugs and b blockers and statins; lack of using exogenous hormones; lack of using amphotericin B,ampicilin, anticoagulant drugs, aspirin, clofibrate, cocaine, lithium, furosemide, morphine and some of anesthetic drugs; lack of using epinephrine and sodium bicarbonate; lack of using orlistate and cholestyramine and other cholesterol reducing drugs; people by BMI group 18.5 to 30; lack of smoking and alcohol consumption; people with 25(oh)D serum concentration less than 40 ng/mL. exclusion criteria: lack of collaboration for continuing the study; using certain drugs during the study; using foods rich in vitamin D specially canned fish, cod fish oil, Salmon and vit D fortified foods; using less than 80 % of supplements; traveling to place with sunny weather during the study; injury or disease occurrence during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Interleukin 6. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;CRP. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;Lactate dehydrogenase. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;Creatine phosphate kinase. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test.;Serum 25-oh vitamin D3 level. Timepoint: before and after the trial: immidiately before the soccer simulated test. Method of measurement: lab test.;Body composition. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Body composition analyzer (BIA).

Secondary

MeasureTime frame
Rating of Perceived Exertion. Timepoint: immidiately after each partof the simulated test. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeed Ghavamzadeh

Urmia university of medical sciences

ghavamzadeh@hotmail.com+98 440000000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026