food allergy. Allergy, unspecified
Conditions
Interventions
Intervention 1: In the intervention group, certain amount of muffin is given to patients and they are monitored for 4 hours under medical observation. Then desensitization with 1.8 muffin's slice is i
Sponsors
Vice chancellor for Research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Years to 15 Years
Inclusion criteria
Inclusion criteria: patients two years and older Presentation of skin symptoms such as urticaria, erythema and angioedema gastrointestinal symptoms such as severe vomiting, abdominal pain and diarrhea respiratory symptoms such as rhinitis and bronchospasm Presentation of the symptoms up to two hours after exposure these symptoms should be present at least in last six months positive skin prick test for cow's milk or measurement of sIgE for cow's milk positive challenge test with cow's milk
Exclusion criteria
Exclusion criteria: cellular immune response that is not mediated by IgE malignancy or severe immunodeficiency disorders using beta blockers uncontrolled severe persistent asthma Cardiovascular disease that epinephrine administration is contraindicated in them Taking immunosuppressive drugs previously diagnosed Eosinophilic Gastrointestinal Disorder in response to milk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regulatory T cell. Timepoint: Before intervention, after intervention. Method of measurement: Flow cytometry.;Specific IGE for milk. Timepoint: Before intervention, after intervention. Method of measurement: RIDA.;Milk Desensitization. Timepoint: Before intervention, after intervention. Method of measurement: Clinical. | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms,anaphylaxis,desensitization. Timepoint: Immediately after intervention. Method of measurement: physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Emad Bahraminiya
Tehran University of Medical Sciences
Outcome results
None listed