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Effect of Fexofenadine and budesonide on the level of transcription factors: GATA-3? ROR?t and FOXP3 in allergic rhinitis patients

A comparison survey of GATA-3, ROR?t and FOXp3 genes expression levels in peripheral blood cells of rhinitis patients, before and after treatment with fexofenadine and budesonide.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017042433622N1
Enrollment
20
Registered
2017-05-16
Start date
2017-05-13
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinitis. Vasomotor and allergic rhinitis and Chronic rhinitis, nasopharyngitis and pharyngitis

Interventions

Fexofenadine: One tablet per day Budesonide: One Puff per day.
Treatment - Drugs
Fexofenadine: One tablet per day Budesonide: One Puff per day

Sponsors

Vice Chancellor for Research and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: the age of man and women between 18 to 60, Signature the testimonial by the patients before entrance to the study, having rhinitis symptoms which is confirmed by specialist physician, lack of abnormality in nasal anatomy, not being suffered from: asthma, infectious disease, underlying diseases such as diabetes and chronic inflammatory diseases. In addition, pregnant women, people above 65 and those people who suffer from rhinitis because of Senility will not enter the study. Exclusion criteria: People suffering from infectious diseases or common cold and patients taking drugs other than drugs that must consume according to the research plan, during Performance of the project? will be excluded. In addition, patients who have a fungal, viral or bacterial disease during the study and patients who do not follow the recommended instructions will be excluded.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
GATA3, FOXP3 and RORgt. Timepoint: Befor treatment and After one month treatment. Method of measurement: Relative expression of GATA3, FOXP3 and RORgt measured by Real-time PCR.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Gorgin Karaji

School of Medicine, Kermanshah University of Medical Sciences

ali4459@gmail.com; ali4459@yahoo.com+98 833427461821

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026