Effect of sedative drugs. Sedatives, hypnotics and antianxiety drugs
Conditions
Interventions
Intervention 1: The first intervention group: 0.2 milligram per kilogram oral midazolam administered once. Intervention 2: The second intervention group: 0.1 milligram per kilogram intravenous midazol
Treatment - Drugs
The first intervention group: 0.2 milligram per kilogram oral midazolam administered once
The second intervention group: 0.1 milligram per kilogram intravenous midazolam
The third intervention group: 50 mg per kg chloral hydrate syrup administered orally once
Sponsors
Vice-chancellor for Research, Birjand University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 12 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age below 12 years; alertness; no respirational distress; no hypotonia. Exclusion criteria: Non-cooperative infant or child despite the use of the sedative where echocardiography cannot be performed (uncooperative patient); uncooperative parents because of side effects of the drug; instability of the patient after taking the drug where s/he needs to be hospitalized in the ICU
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of sedation. Timepoint: At the time of sleepiness of the patient. Method of measurement: Richmond Agitation-Sedation Score.;Onset of sedative effect. Timepoint: Every 2 minutes from drug prescription until sleepiness. Method of measurement: observation.;Duration of sedative effect. Timepoint: Every 5 minutes from sleepiness onset until total alertness. Method of measurement: Observation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Gestational complications (including nausea and vomitting). Timepoint: From drug administration for an hour. Method of measurement: Observation.;Respirational complications (Apnea). Timepoint: From drug administration for an hour. Method of measurement: Observation.;Nervous complications (Agitation). Timepoint: From drug administration for an hour. Method of measurement: Observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Ebrahimzadeh
Birjand University of Medical Sciences
Outcome results
None listed