coronary artery disease. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: In the intervention model, conventional ultrafiltration will be performed during operation and modified ultrafiltration will be applied after cardiopulmonary bypass. Intervention 2: In
Treatment - Other
In the intervention model, conventional ultrafiltration will be performed during operation and modified ultrafiltration will be applied after cardiopulmonary bypass.
In the control group, only conventional ultrafiltration will be applied during operation.
Sponsors
Vice Chancellor for Research, Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients candidated for cardiopulmonary bypass surgery; cardiopulmonary bypass time from 50 to 120 minutes; number of grafts 3 or 4,/ Exclusion criteria: patient denying to participate in the study; cardiac conditions/comorbidities affecting the recovery after sternotomy; previous history of cardiac arrest; use of defibrilator during operation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ROTEM parameters. Timepoint: After declamp, after separation from pump, 24 hours after operation. Method of measurement: Plasma analysis using ROTEM machine.;Hemoglobin and hematocrit. Timepoint: Before and after operation. Method of measurement: Biochemical analysis.;Inflammatory cytokine response (IL-6, -8, -10 and TNF-alpha). Timepoint: After declamp, after separation from pump, 24 hours after operation. Method of measurement: Plasma analysis using ELISA technique. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarhad Gorjipour
Rajaie Cardiovascular Medical and Research Center
Outcome results
None listed