Effect of vitamin D supplementation in cigarette smokers

The effects of vitamin D supplementation on mental health parameters, oxidative stress and inflammatory biomarkers in cigarette smokers

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170420033551N7

Enrollment

Registered

2019-07-15

Start date

2019-06-10

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine dependence in cigarette smokers. Nicotine dependence, cigarettes

Interventions

Intervention 1: Intervention group: 50000 IU vitamin D (Zahravi, Tabriz, Iran), once every 2 weeks, for 24 weeks orally. Intervention 2: Control group: Placebo (Barij Essence, Kashan, Iran), once ever

Eligibility

Sex/Gender

All

Age

17 Years to 60 Years

Inclusion criteria

Inclusion criteria: Smoking dependence Age of 17 to 60 years old

Exclusion criteria

Exclusion criteria: Suicide attempts within the past 12 months or either suicidal ideations or psychotic symptoms in the past 6 months as determined by a study physician Current opioid, alcohol or sedative physical dependence or cocaine dependence Metabolic diseases such as diabetes and neurological diseases such as epilepsy Unwillingness to cooperate Current severe depression and mania psychosis

Design outcomes

Primary

Measure	Time frame
Depression beck score. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Questionnaire.;Anxiety beck score. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Total antioxidant. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Spectrophotometry.;HDL. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Triglycerides. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Fasting plasma glucose. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Insulin. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Elisa kit.;Nitric oxide. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Spectrophotometry.;Hs-CRP. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Elisa kit.;Total glutathione. Timepoint: At the beginning of the study and 24 weeks after intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and 24 weeks after intervention. Method of measurement: Spectrophotometry.	—

Measure

Time frame

Total antioxidant. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Spectrophotometry.;HDL. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Triglycerides. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Fasting plasma glucose. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Enzymatic kit.;Insulin. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Elisa kit.;Nitric oxide. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Spectrophotometry.;Hs-CRP. Timepoint: At the beginning of the study and after 24 weeks of intervention. Method of measurement: Elisa kit.;Total glutathione. Timepoint: At the beginning of the study and 24 weeks after intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and 24 weeks after intervention. Method of measurement: Spectrophotometry.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Ghaderi

Kashan University of Medical Sciences

gaderiam@yahoo.com+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026