Addiction. Other psychoactive substance related disorders
Conditions
Interventions
Intervention 1: Intervention group: tablet of crocin, 15 mg, two oral tablet for 12 weeks. Intervention 2: Control group: placebo tablet, two oral tablet for 12 weeks.
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients on methadone maintenance treatment Age of 18 to 70 years old Evaluated by the drug abuse section of the Structured Clinical Interview for DSM-IV Seeking for treatment
Exclusion criteria
Exclusion criteria: Unwillingness to cooperate Current severe depression and mania Psychosis Consumption of crocin, antioxidant, and anti-inflammatory supplements during the last 3 months High blood pressure Hypothyroidism or hyperthyroidism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Craving. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Desire for Drug Questionnaire (DDQ craving).;Withdrawal syndrome. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Clinical opiate withdrawal symptoms (COWS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of cognitive function. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: Cognitive function questionnaire.;Verba Fluency. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: FAS task.;Speed Processing. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: Digit Symbol and Trial Making Test (TMT).;Memory. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: Wechsler intelligence Scale (DGSP). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Ghaderi
Kashan University of Medical Sciences
Outcome results
None listed