The effect of folic acid on migraine headache

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017041920258N39

Enrollment

Registered

2017-06-03

Start date

2015-08-25

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine

Interventions

Intervention 1: Intervention group 1:10 milligram nortriptyline nightly with 200 milligram Depakin daily and folic acid 1 milligram daily. Intervention 2: Intervention group 2: 10 milligram nortrip

Treatment - Drugs

Intervention group 1:10 milligram nortriptyline nightly with 200 milligram Depakin daily and folic acid 1 milligram daily.

Intervention group 2: 10 milligram nortriptyline nightly with 200 milligram Depakin daily and folic acid 5 milligram daily

Control group: 10 milligram nortriptyline nightly with 200 milligram Depakin daily.

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 20-50 years; getting no treatment for Migraine in the previous 3 months; not being pregnant or lactating; having no systemic disease or intracranial lesion. Exclusion criteria: any drug side ?effects

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Headache. Timepoint: monthly after start of treatment to 3 months. Method of measurement: MIDAS questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Maleki rad

Valiasr hospital

Malekirad@arakmu.ac.ir+98 863222003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026