Evaluating effect of vitamin C on reducing harmful effect of radioiodine

Protective and mitigatory effect of oral vitamin C against radiation-induced serum stress oxidative in thyroid cancer patients ablated with high dose of radioiodine

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017041833505N1

Enrollment

Registered

2017-05-26

Start date

2017-05-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thyroid cancer. Malignant neoplasm of thyroid gland

Interventions

Intervention 1: Intervention group: Used drug will be effervescent tablets of vitamin C. Intervention group will have three sub-groups. 1- A sub-group which 2 days before radioiodine therapy will star

Treatment - Drugs

Placebo

Intervention group: Used drug will be effervescent tablets of vitamin C. Intervention group will have three sub-groups. 1- A sub-group which 2 days before radioiodine therapy will start taking 3 tab

Placebo group: A groups will be performed routine treatment. Just for placebo, water and some juice will be used.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: The patient has a suitable general condition; no kidney disease; radioiodine dose more than 150 millicuries; signing informed consent. Exclusion criteria: The patient doesn't cooperate during intervention for taking the vitamin.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Catalase. Timepoint: Before and after intervention. Method of measurement: Reduce of absorption of H2O2 at 240nm by Spectrophotometric method.;Superoxide Dismutase. Timepoint: Before and after intervention. Method of measurement: Using Misra and Fridovich method based on the inhibition of spontaneous oxidation of adrenaline to adrenochrome by SOD in 10.2pH. Maximum light absorption of adrenochrome is at wavelength of 480nm.;Glutathione. Timepoint: Before and after intervention. Method of measurement: Using Elman method which DTNB is added to all of Super Natants and after that absorption in 412 nm is read.;Malondialdehyde. Timepoint: Before and after intervention. Method of measurement: Colorimetric method with a spectrophotometer at a wavelength of 532 nm and in nano gram per ml.	—

Measure

Time frame

Catalase. Timepoint: Before and after intervention. Method of measurement: Reduce of absorption of H2O2 at 240nm by Spectrophotometric method.;Superoxide Dismutase. Timepoint: Before and after intervention. Method of measurement: Using Misra and Fridovich method based on the inhibition of spontaneous oxidation of adrenaline to adrenochrome by SOD in 10.2pH. Maximum light absorption of adrenochrome is at wavelength of 480nm.;Glutathione. Timepoint: Before and after intervention. Method of measurement: Using Elman method which DTNB is added to all of Super Natants and after that absorption in 412 nm is read.;Malondialdehyde. Timepoint: Before and after intervention. Method of measurement: Colorimetric method with a spectrophotometer at a wavelength of 532 nm and in nano gram per ml.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEsmaeil Jafari

Shiraz University of Medical Sciences

esmaeiljafari70@yahoo.com+98 917 642 2993

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026