Investigating the effect of high-density transcranial electrical stimulation (HD-tDCS) over the ventrolateral prefrontal cortex (VLPFC) in improving reappraisal

Investigating the effect of high-density transcranial electrical stimulation (HD-tDCS) over the ventrolateral prefrontal cortex (VLPFC) in improving reappraisal and sustained attention in healthy individuals: A double-blind, randomized, sham-controlled clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170417033485N6

Enrollment

Registered

2025-12-26

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

emotion dysregulation.

Interventions

Intervention 1: Intervention group: Participants in this group receive the study-designed intervention aimed at examining its effects on emotion regulation and cognitive performance. Intervention 2: C

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age range 18 to 45 Physical health and mental health Male gender Absence of underlying systemic diseases and neurological and mental disorders No history of taking any medication regularly No history of drug or stimulant substances use

Exclusion criteria

Exclusion criteria: Lack of willingness to continue participation or inability to complete the assessment and testing procedures Presence of any disease, disorder, or specific medical condition identified or reported during the course of the study Occurrence of intolerance or adverse reactions to HD-tDCS stimulation

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is the change in emotion regulation ability, assessed using the Cognitive Emotion Regulation Questionnaire (CERQ). Total and subscale scores will be measured at baseline and 30 minutes after the intervention, and changes between these time points will be analyzed as the primary outcome. Timepoint: Baseline and 30 minutes after the intervention. Method of measurement: Cognitive Emotion Regulation Questionnaire (CERQ), including total and subscale scores.	—

Measure

Time frame

The primary outcome of this study is the change in emotion regulation ability, assessed using the Cognitive Emotion Regulation Questionnaire (CERQ). Total and subscale scores will be measured at baseline and 30 minutes after the intervention, and changes between these time points will be analyzed as the primary outcome. Timepoint: Baseline and 30 minutes after the intervention. Method of measurement: Cognitive Emotion Regulation Questionnaire (CERQ), including total and subscale scores.

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Secondary

Measure	Time frame
The secondary outcomes of this study include cognitive performance, assessed using the Paced Auditory Serial Addition Test (PASAT). Performance indices include response accuracy and reaction time, and changes between baseline and 30 minutes after the intervention will be analyzed as secondary outcomes. Timepoint: Baseline and 30 minutes after the intervention. Method of measurement: Paced Auditory Serial Addition Test (PASAT) score.	—

Measure

Time frame

The secondary outcomes of this study include cognitive performance, assessed using the Paced Auditory Serial Addition Test (PASAT). Performance indices include response accuracy and reaction time, and changes between baseline and 30 minutes after the intervention will be analyzed as secondary outcomes. Timepoint: Baseline and 30 minutes after the intervention. Method of measurement: Paced Auditory Serial Addition Test (PASAT) score.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Mohammadi

Bagheiat-allah University of Medical Sciences

ar.mohammadi@bmsu.ac.ir+98 21 2612 7281

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026