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Clinical trial the effect of intravenous ondansetron and sub-hypnotic propofol dose on pruritus after intrathecal opioid in patient with elective cesarean surgery

Comparison the effect of intravenous ondansetron and sub-hypnotic propofol dose on pruritus after intrathecal opioid in patient with elective cesarean surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017041527677N7
Enrollment
90
Registered
2017-07-21
Start date
2016-07-27
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: opioid induced pruritus. Condition 2: nausea and vomiting. Pruritus, unspecified Vomiting of pregnancy, unspecified

Interventions

Intervention 1: Intervention group 1: Immediately after clamping the umbilical cord for first study group ondansetron 4 mg (Exir Company) by intravenous will be injected. Intervention 2: Intervention
Treatment - Drugs
Intervention group 1: Immediately after clamping the umbilical cord for first study group ondansetron 4 mg (Exir Company) by intravenous will be injected.
Intervention group 2: Immediately after clamping the umbilical cord for second study group 10 mg propofol (Fresnius Kabi Company) and then 10 µg/kg/min will be infused intraoperative.

Sponsors

Vice Chancellor for research of Urmia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:20 to 40 years old; patient with class I and II America society of Anesthesiologists; cesarean surgery with spinal anesthesia Exclusion criteria: any complaints of pruritus before surgery; start pruritus before closing cord; allergy to medications; preeclampsia; eclampsia; people who had used anti-nausea drug in the past 24 hours.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pruritus. Timepoint: During the surgery and recovery. Method of measurement: visual analog scale.

Secondary

MeasureTime frame
Nausea and vomiting. Timepoint: During the surgery and recovery. Method of measurement: Has- does not have.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahryar Sane

Urmia University of Medical Sciences

sane.sh@umsu.ac.ir; shahryarsane@yahoo.com; dr.sh.sane@gmail.com+98 44 3222 4777

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026