knee osteoarthritis. Gonarthrosis [arthrosis of knee]
Conditions
Interventions
Intervention 1: Intervention group 1: Hyaluronic acid, knee intraarticuar injection, 20mg/2ml solution, 3 times, 1 week interval. Intervention 2: Intervention group 2: Ozone-Oxygen solution, knee intr
Treatment - Drugs
Intervention group 1: Hyaluronic acid, knee intraarticuar injection, 20mg/2ml solution, 3 times, 1 week interval
Intervention group 2: Ozone-Oxygen solution, knee intraarticuar injection, 10 milliliter, 3 times, 1 week interval
Sponsors
Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: age between 45-75 years; symptomatic knee OA with the pain aggravated by weight bearing; symptoms lasting for at least 6 months despite conservative treatments; Kellgren-Lawrance radiologic scoring (KLS) system scores ranging from 2-3 Exclusion Criteria: history of trauma, surgery or any invasive procedure in the affected joint during the past 6 months; mal-alignment in lower limbs and abnormal blood count or impaired coagulation tests; pregnant women; patients who were under immunosuppressant treatments; those with an underlying systemic arthropathy (secondary OA); patients being treated with angiotensin converting enzyme inhibitors (ACEI) and significant deficiency in glucose 6-phosphate dehydrogenase (G6PD) level
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Patient Function. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: before intervention & 6 months after intervention. Method of measurement: VAS.;Joint stiffness. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire. | — |
Primary
| Measure | Time frame |
|---|---|
| Knee pain. Timepoint: before intervention & 6 months after last intervention. Method of measurement: WOMAC questionnair. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahram Rahimi Dehgolan
Physical Medicine and Rehabilitation Department, Shahid Beheshti University of Medical Sciences, Sch
Outcome results
None listed