Coronary artery surgery. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: First group: Bolus intravenous infusion of 50 micrograms fentanyl followed by pump infusion of 5 to 50 micrograms per cc in speed in hour. Intervention 2: Second group: bolus intraveno
Treatment - Drugs
First group: Bolus intravenous infusion of 50 micrograms fentanyl followed by pump infusion of 5 to 50 micrograms per cc in speed in hour
Second group: bolus intravenous infusion of 0.5 millirograms per kilogram of ketamine followed by pump infusion of 0.5 millirograms per kilogram in hour.
Sponsors
Vice chancellor for research, Zahedan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Main inclusion criteria: pre-operation ejection fraction above 30%; class one to three of ASA; no simultaneous heart valves involvement; no need of intra-aortic pump usage during the operation. Main exclusion criteria: positive history of sensitivity to study drugs; uncontrolled systemic disease such as diabetes; addiction to alcohol and drugs; positive history of psychologic disease and depression; asthma and other hypersensitivity reactions; intraoperative fracture of sternum and ribs; pre-operative liver enzymes rising higher than two folds; other chest pain causes other than coronary arteries; presence of neurologic signs and symptoms; any type of consciousness impairment pre-operation.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperation pain. Timepoint: Two houres, four houres, eight houres, 12 houres and 24 houres after surgery. Method of measurement: VAS Criteria.;Mean arterial pressure. Timepoint: Up to 24 hours after surgery in intervals of every 4 hours. Method of measurement: Millimeter of mercury.;Heart rate. Timepoint: Up to 24 hours after surgery in intervals of every 4 hours. Method of measurement: Beats in minute. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarziye Yousefi
Zahedan University of Medical Sciences
Outcome results
None listed