Comparison of the effect of ethinyl estradiol with sildenafil citrate versus ethinyl estradiol on endometrial thickness in infertile women

Comparison of the effect of ethinyl estradiol with sildenafil citrate versus ethinyl estradiol on endometrial thickness in infertile women: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201704119014N156

Enrollment

Registered

2017-04-12

Start date

2016-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Intervention group: Vaginal ethinyl estradiol 5 mg 4 times a day plus vaginal sildenafil citrate 25 mg 4 times a day for 2 weeks. Intervention 2: Control group: Vaginal ethinyl estradi

Treatment - Drugs

Intervention group: Vaginal ethinyl estradiol 5 mg 4 times a day plus vaginal sildenafil citrate 25 mg 4 times a day for 2 weeks.

Control group: Vaginal ethinyl estradiol 5 mg 4 times a day for 2 weeks.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 18 to 40 years; male factor Infertility; no response to ovulation induction and intrauterine inoculation of semen. Exclusion criteria: Hydrosalpinx in one or both tubes; smoker; absence of at least two reached follicles following treatment; absence of fetus or at least one fetus.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Assessing the endometrial thickness. Timepoint: one and two weeks after treatment. Method of measurement: using transvaginal sonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Artimis Sadeghian

Fatemieh Hospital

art_sadeghian@yahoo.com+98 81 3828 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026