Comparison of Gabapentin, Pregabalin and placebo as premedication for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017041133365N1

Enrollment

Registered

2017-06-24

Start date

2017-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laryngoscopy and intubation in elective surgery.

Interventions

Intervention 1: Group III will receive oral pregabalin 150 mg (Sobhan) 2 h prior surgery. Intervention 2: Control group will receive oral placebo 2 h before surgery. Intervention 3: Group II will rece

Treatment - Drugs

Group III will receive oral pregabalin 150 mg (Sobhan) 2 h prior surgery

Control group will receive oral placebo 2 h before surgery

Group II will receive oral gabapentin 900 mg (Razak), 2h before surgery

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 20-50 yrs old; physical status I, II; elective surgery under general anesthesia; tracheal intubation with cuffed tube. Exclusion criteria: Morbid obesity; history of allergy; history of study drugs consumption.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
HR. Timepoint: 1,3, and 5 min after intubation. Method of measurement: Monitoring.;Systolic BP. Timepoint: 1,3, and 5 min after intubation. Method of measurement: Monitoring.;Diastolic. Timepoint: 1,3, and 5 min after intubation. Method of measurement: Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Mahoori

Urmia University of Medical Sciences

at_mahoori@yahoo.com+98 44 3346 8967

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026