Investigating the effect of ketorolac and meperidine on shivering after laparoscopic cholecystectomy surgery

A comparative study of the effects of ketorolac and meperidine on postoperative shivering after laparoscopic cholecystectomy under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170411033365N6

Enrollment

Registered

2024-10-21

Start date

2024-11-21

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative shivering. shivering

Interventions

Intervention 1: Intervention group: Patients in one group will receive meperidine 30 mg intravenously in recovery. Intervention 2: Intervention group: Patients in the other group will receive ketorola

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients undergoing laparoscopic cholecystectomy under general anesthesia Age 20 to 70 years Class I and II according to the American Society of Anesthesiology (ASA I-II)

Exclusion criteria

Exclusion criteria: Allergy to non-steroidal anti-inflammatory drugs (NSAIDs) Renal problems

Design outcomes

Primary

Measure	Time frame
Severity of shivering. Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Mean arterial pressure. Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.;Heart rate. Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.;Systolic blood pressure (SBP). Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.;Diastolic blood pressure (DBP). Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.	—

Measure

Time frame

Mean arterial pressure. Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.;Heart rate. Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.;Systolic blood pressure (SBP). Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.;Diastolic blood pressure (DBP). Timepoint: 5, 10, 15, 20, 30 minutes after the intervention. Method of measurement: Monitoring device.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Mahouri

Oroumia University of Medical Sciences

mahouri.a@umsu.ac.ir+98 44 3345 7286

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026