Assessment of the prophylactic combined effect of diphenhydramine with paracetamol on agitation and pain after laparoscopic cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170411033365N4

Enrollment

Registered

2022-07-20

Start date

2022-08-22

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystectomy.

Interventions

Intervention 1: Intervention group: In group (P), intravenous paracetamol will be injected simultaneously for more than 15 minutes (1 g of paracetamol per 100 ml of 0.9% NaCl) 10 minutes after inducti

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age group 20 to 60 years Patients with ASA class one and two undergo laparoscopic cholecystectomy Selective general anesthesia

Exclusion criteria

Exclusion criteria: Patients aged 20 to 60 years with ASA class one and two undergoing laparoscopic cholecystectomy

Design outcomes

Primary

Measure	Time frame
Agitation and pain. Timepoint: In recovery and after transfer to the ward at 6, 12 and 24 hours after surgery. Method of measurement: The amount of visual scoring pain (VAS) from zero to 10 points and the amount of agitation at the time of recovery after 10, 20, 30 minutes after recovery, by four-point scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Mahouri

Oroumia University of Medical Sciences

Mahouri.a@umsu.ac.ir+98 44 3346 9931

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026