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Comparative addition of Dexmedetomidini and fentanyl to intrathecal bupivacaine in orthopaedic procedure in lower limbs

Comparative addition of Dexmedetomidini and fentanyl to intrathecal bupivacaine in orthopaedic procedure in lower limbs

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017041010599N15
Enrollment
78
Registered
2017-05-24
Start date
2017-04-08
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regional anesthesia.

Interventions

Intervention 1: First group was put on 5 micro dexmedetomidini mixed whith normal saline up to 5cc with 2.5 cc bupivacaine 0.5%. Intervention 2: Second group put on 25 micro Fentanyl with 2.5 cc bupiv
Treatment - Drugs
First group was put on 5 micro dexmedetomidini mixed whith normal saline up to 5cc with 2.5 cc bupivacaine 0.5%.
Second group put on 25 micro Fentanyl with 2.5 cc bupivacaine 0.5%
Control group put on 0.5 cc normal saline whith 2.5 cc bupivacaine 0.5%

Sponsors

Vice-Chancellor of research Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: In our study 78 patients in ASA1-2 whit in the ages of 20-65 that attended hospital for elective orthopaedic surgery in lower limbs at Rasool Akram hospital Tehran, Iran were recruited. Exclusion criteria are: addiction; renal or hepatic failure; disrhythmic heart disease or heart block; allergy to drugs and spinal contraindications such as coagulopathy disorders, injection site infection.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Lenght of sensory block. Timepoint: Sensory level mesured every 2 minutes to higher level then mesured every 10 minutes to regresion of 2 level then every 20 minutes to regresion S1. Method of measurement: Pin prick method in midclavicular linewhith 23 gage needle.;Lengs of motor block. Timepoint: Time to Bromage 3 and regresion to bromage 0. Method of measurement: Modified bromage.;Speed of sensory block. Timepoint: Time to T10 and above dermatom. Method of measurement: Pin prick method in midclavicular line whith 23 gage needle.;Speed of motor block. Timepoint: Time to Bromage 3. Method of measurement: Modified bromage.;Sensory level. Timepoint: Sensory level mesured every 2 minutes to higher level then mesured every 10 minutes to regresion of 2 level then every 20 minutes to regresion S1. Method of measurement: Upper sensory level with pin prick method in midclavicular linewhith 23 gage needle.

Secondary

MeasureTime frame
Blood presure drop. Timepoint: Before and imediatly after injection then every minute to 10 minute and then every 5 minute. Method of measurement: NIBP.;Heart rate drop. Timepoint: Before and imediatly after injection then every minute to 10 minute and then every 5 minute. Method of measurement: Manitoring system.;Need to drug. Timepoint: Before and imediatly after injection then every minute to 10 minute and then every 5 minute. Method of measurement: Registrying by anesthetic doctor or technitian.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaied Amniati

Iran University of Medical Sciences

sa_amniati@yahoo.com+98 21 6655 0499

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 24, 2026