Myocardial infarction. Acute myocardial infarction
Conditions
Interventions
Intervention 1: In the intervention group:
patients in intervention group receive a 200 mg net hesperidin supplements daily for 12 weeks with the main meal. Intervention 2: In the control group:
pat
Treatment - Drugs
In the intervention group:
patients in intervention group receive a 200 mg net hesperidin supplements daily for 12 weeks with the main meal.
In the control group:
patients in control group receive a capsules similar to hesperidin supplements containing 200 mg starch daily for 12 weeks with the main meal.
Sponsors
Iran university of medical science
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Risk of myocardial infarction,According to to diagnosis of profession and clinical symptoms Including:1.Chest pain for at least 20 minutes.2.Clearly electrocardiographic changes.3.Evidence of increased cardiac enzyme levels(According to :Depression treatment after myocardial infarction and long term risk of subsequent cardiovascular events and mortality:A randomized controlled tial article);The patient agreed to enter the study and willingness to cooperate and Signed informed consent;The use of any supplements, including:Antioxidant and vitamins during the last 3 months;The absence of any allergies(Gastrointestinal and skin) to Each type of antioxidant supplements and vitamins;MI Patients with up to 6 weeks after discharge ;40-25:BMI;30-70:Age;Not taking more than one blood orange or two of other citrus in a day Exclusion criteria:Lack of follow-up after discharge;Patient dissatisfaction or Not wanting to continue the cooperation of the patient for any reason ;The use of antioxidant supplements and vitamins and Q10 supplement;Find allergy symptoms at any time during the study; Suffering from Uncontrolled chronic diseases(Liver dysfunction, kidney failure, diabetes, etc.);Gastrointestinal disorders Compliance below the 80%;Taking antibiotics and catching infectious diseases No entry criteria:Taking more than 500 ml per day of drinks and food sources rich in flavonoids(Green tea, coffee, citrus juice, which is determined through a entry criteria questionnaire;Dont use of heparin and Varfarin;Unable to follow-up patient after discharge;Smoking and tobacco;Any allergies to any kind of vitamin supplements;Pregnancy and lactation;Suffering from any Uncontrolled metabolic disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P-Selectin. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;Fasting blood glucose. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;Triglyceride. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;Total cholestrol. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;LDL cholestrol. Timepoint: Before intervention and three months after intervention. Method of measurement: formula.;HDL cholestrol. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;PON 1. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;Hs-CRP. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;Diastolic pressure. Timepoint: Before intervention and three months after intervention. Method of measurement: Barometer.;Systolic pressure. Timepoint: Before intervention and three months after intervention. Method of measurement: Barometer.;OX-LDL. Timepoint: Before intervention and three months after intervention. Method of measurement: Plasma samples.;Conicity Index. Timepoint: Before intervention and three months after intervention. Method of measurement: formula.;Body composition. Timepoint: Before intervention and three months after intervention. Method of measurement: e-body instrument. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass Index. Timepoint: Before intervention and after intervention. Method of measurement: formula.;Anthropometric indices. Timepoint: Before intervention and after intervention. Method of measurement: Meters and scales.;Physical activity. Timepoint: Before intervention and after intervention. Method of measurement: IPAQ questionnaire.;Food intake. Timepoint: Before intervention and between and after intervention. Method of measurement: 3 day 24 hour food recall. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr mohammadreza Vafa
Vice President of Research of Iran university of medical science
Outcome results
None listed