Comparison the effects of Dexmedetomidine and Labetalol on blood pressure in maxillofacial fractures surgery

Comparison the effects of Dexmedetomidine and Labetalol for induced hypotension in maxillofacial fractures surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170408033291N3

Enrollment

Registered

2019-12-30

Start date

2018-12-22

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fracture of mandible. Fracture of mandible

Interventions

Intervention 1: First intervention group: Patients in the first group receive dexmedetomidine with bolus infusion of 1µg/kg/h and maintenance dose of 3.0 -5.0 µg/kg/h. Intervention 2: Second intervent

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Ages 18 to 60 years Class 1 & 2 of American Anesthesiologists (ASA) Association Classification Fracture of mandible or maxilla

Exclusion criteria

Exclusion criteria: Class 3 or more of American Anesthesiologists (ASA) Association Classification Heart Block Heart Failure Unstable Hemodynamic Depression Renal Failure Raynaud's phenomenon Sensitivity to lidocaine or beta-blockers Deformity of Trachea Lack of consent to participate in the study

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using a blood pressure monitor device.;Diastolic blood pressure. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using a blood pressure monitor device.;Mean arterial blood pressure. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using a blood pressure monitor device.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using a blood pressure monitor device.;Diastolic blood pressure. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using a blood pressure monitor device.;Mean arterial blood pressure. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using a blood pressure monitor device.

—

Secondary

Measure	Time frame
Heart Rate. Timepoint: Before surgery, after intubation, after induction of hypotension, after bolus dose, 3, 5, 10, 15, 30, 60 min after bolus dose, end of operation and recovery. Method of measurement: Using cardiac monitoring device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAydin Binazadeh

Qazvin University of Medical Sciences

binazadehaydin@gmail.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026