Effect of Azithromycine (AZM) on gingival overgrowth

The evaluation of the effect of Azithromycine on inflammatory and fibroblastic part of Cyclosporine (CsA) induced gingival overgrowth in renal transplanted patients with and without scaling

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017040529321N2

Enrollment

Registered

2017-08-15

Start date

2010-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gingival enlargement. gingival fibromatosis

Interventions

Intervention 1: control:Drug Two 250 miligram Azithromycine capsule at first day and then one 250 miligram Azithromycine capsule daily for 4 days. Intervention 2: Intervention: Scaling

Treatment - Drugs

Treatment - Other

control:Drug Two 250 miligram Azithromycine capsule at first day and then one 250 miligram Azithromycine capsule daily for 4 days

Intervention: Scaling Drug Two 250 miligram Azithromycine capsule at first day and then one 250 miligram Azithromycine capsule daily for 4 days

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: transplanted patients with systemic use of CsA; more than 18 year old; existing upper and lower 6 teeth of anterior segment; gingival overgrowth in grade 1 based on King Index; plaque index more than 10% Exclusion criteria: hypersensitivity for macrolid antibiotics; not having stable renal function; having any periodontal treatment after transplantation; local irritation in Maxiillary and Mandibular anterior teeth; Oral breathing; smoking

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Gingival enlargement. Timepoint: Before intervention, 4,8,12,16 weeks after intervention. Method of measurement: Periodontal probe.	—

Secondary

Measure	Time frame
Gingivitis. Timepoint: Before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: Observation, periodontal probe.;Dental plaque. Timepoint: Before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: observation, plaque disclosing tablet.;Clinical crown length. Timepoint: before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: Periodontal probe.;Probing depth. Timepoint: Before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: periodontal probe.	—

Measure

Time frame

Gingivitis. Timepoint: Before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: Observation, periodontal probe.;Dental plaque. Timepoint: Before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: observation, plaque disclosing tablet.;Clinical crown length. Timepoint: before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: Periodontal probe.;Probing depth. Timepoint: Before intervention, 4, 8, 12, 16 weeks after intervention. Method of measurement: periodontal probe.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara beyhaghi

Private office

sara_bey2000@yahoo.com+98 51 4422 7121

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026