Comparison between Intravenous Xylocaine, Mg sulfate and Amiodarone in the Prevention of Cardiac Arrhythmias after Aortic Declamping in Coronary Artery Bypass Surgery

Comparison between Intravenous Xylocaine, Mg sulfate and Amiodarone in the Prevention of Cardiac Arrhythmias after Aortic Declamping in Coronary Artery Bypass Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017040519470N55

Enrollment

200

Registered

2017-06-22

Start date

2017-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Surgery. Atherosclerotic heart disease

Interventions

Intervention 1: Intervention group 1: patients received 1.5 mg / kg lidocaine, intravenous immediately before declamping. Intervention 2: Intervention group 2: patients received 2 mg of magnesium sulf

Treatment - Drugs

Placebo

Intervention group 1: patients received 1.5 mg / kg lidocaine, intravenous immediately before declamping.

Intervention group 2: patients received 2 mg of magnesium sulfate intravenous immediately before declamping.

Intervention group 3: patients received 150 mg Amiodarone intravenous immediately before declamping.

Control group: patients received 5 CC normal saline immediately before declamping.

Sponsors

Vice Chancellor for Research, Shiraz University of Medical Sciences

Lead Sponsor

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients undergoing elective surgery for coronary artery bypass surgery. Exclusion criteria: history of using antiarrhythmic drugs; heart block (RBBB-LBBB-LAHB-LPHB) or pacemakers.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Arrhythmias. Timepoint: after aortic cross declamping perioperatively. Method of measurement: EKG monitoring.;Total inotropes consumption. Timepoint: Perioperatively. Method of measurement: Observasion.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Allahyari

Shiraz University of Medical Sciences

allahyarye@sums.ac.ir+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026