Clinical trial the effect of granisetron and dexamethasone on intravenous propofol pain in patient whit dilatation and curettage surgery

Comparison the effect of granisetron and dexamethasone on intravenous propofol pain

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017040427677N6

Enrollment

141

Registered

2017-05-10

Start date

2015-12-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain of propofol injection. Generalized pain NOS

Interventions

Intervention 1: Intervention group 2: Dexamethasone will be prepared in 5 cc syringes and after closing cord randomly injected. Intervention 2: Intervention group 1: Granisetron will be prepared in 5

Treatment - Drugs

Intervention group 2: Dexamethasone will be prepared in 5 cc syringes and after closing cord randomly injected.

Intervention group 1: Granisetron will be prepared in 5 cc syringes randomly injected.

Control group: Normal Saline will be prepared in 5 cc syringes randomly injected.

Eligibility

Sex/Gender

Female

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: physical status class I and II from the perspective of America society of Anesthesiologists; dilatation and curettage surgery; 20 to 50 years old Exclusion criteria: Patients with a history of Allergies to propofol or 5-hydroxytryptamine receptor antagonists or dexamethasone; Patients who received any medication for analgesia or sedation in the past 24 hours; Severe mental disorders; Neuromuscular disease; ischemic heart disease; Uncontrolled hypertension; Renal and hepatic disease; Convulsion disease; Body mass index over 30; Chronic use of any drugs; Gastrointestinal disorders; History of osteoporosis; History of diabetes

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain of propofol injection. Timepoint: Induction of Anesthesia. Method of measurement: visual analog scale.	—

Secondary

Measure	Time frame
Mean pulse Rate. Timepoint: Before injection, 1, 3, 5, 10 minutes after injection. Method of measurement: Electrocardiogram.;Mean Arterial Blood Pressure. Timepoint: Before injection, 1, 3, 5, 10 minutes after injection. Method of measurement: None Invasive Blood Pressure.;Os saturation. Timepoint: Before injection, 1, 3, 5, 10 minutes after injection. Method of measurement: Pulse Oximetry.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahryar Sane

Urmia University of Medical Sciences

sane.sh@umsu.ac.ir; shahryarsane@yahoo.com; dr.sh.sane@gmail.com+98 44 3222 4777

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026