The effect of gabapentin on intrathecal opioid-induced pruritus

Evaluation of prophylactic effect of gabapentin on intrathecal fentanyl-induced pruritus in orthopedic patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017033025600N4

Enrollment

Registered

2017-05-21

Start date

2017-04-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intrathecal opioid-induced pruritus. Opioids and related analgesics

Interventions

Intervention 1: 600 milligram oral gabapentin, 2 hours before intrathecal fentanyl injection. Intervention 2: Oral placebo 2 hours before intrathecal fentanyl injection.

Treatment - Drugs

Placebo

600 milligram oral gabapentin, 2 hours before intrathecal fentanyl injection

Oral placebo 2 hours before intrathecal fentanyl injection

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: male and female patients with class I-II American Society of Anesthesiologist (ASA) aged 20-50 scheduled for elective lower limb orthopedic surgery under spinal anesthesia Exclusion criteria: any contraindication of spinal anesthesia; any pruritus before surgery; known history of allergy to gabapentin; morbid obesity; history of skin disease and any systemic disorder accompanying pruritus

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Intrathecal fentanyl-induced pruritus. Timepoint: At hours 1, 6, 12 and 24 after intratethcal fentanly injection. Method of measurement: Check list.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Shahram Shokohi

Urmia University Of Medical Sciences

shokohi.sh@umsu.ac.ir; dr.shokohi@gmail.com; shokohi725@yahoo.com+98 44 3346 8967

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026